In a mixing bowl, combine the ground beef, salt, black pepper, garlic powder, onion powder, and Worcestershire sauce.

Mix gently until just combined; avoid overmixing to keep the patties tender.

Divide the mixture into 4 equal portions and shape them into patties, about ¾ inch thick.

Make a slight indentation in the center of each patty to prevent puffing during cooking.

Preheat the grill or skillet over medium-high heat.

Cook the patties for about 4-5 minutes on each side for medium doneness, or until desired doneness is reached.

Let the patties rest for a few minutes before serving.